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doi: 10.1242/10.1242/dev.00501

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Development 130, 2997-3005 (2003)
Copyright © 2003 The Company of Biologists Limited

giant nucleiis essential in the cell cycle transition from meiosis to mitosis

Andrew D. Renault1,*, Xiao-Hua Zhang1, Luke S. Alphey1, Lisa M. Frenz2, David M. Glover3, Robert D. C. Saunders4 and J. Myles Axton1,{dagger}

1 Department of Zoology, University of Oxford, South Parks Road, Oxford, OX1 3PS, UK
2 Polgen Division, Cyclacel, Babraham Bioincubator 405, Babraham Institute, Babraham, Cambridgeshire CB2 4AT, UK
3 Department of Genetics, University of Cambridge, Downing Street, Cambridge, CB2 3EH, UK
4 Department of Biological Sciences, The Open University, Walton Hall, Milton Keynes, MK7 6AA, UK
* Present address: Skirball Institute, Developmental Genetics Program, New York University Medical Center, 540 First Avenue, NY 10016, USA

{dagger} Author for correspondence (myles.axton{at}zoo.ox.ac.uk)

Accepted 14 March 2003

At the transition from meiosis to cleavage mitoses, Drosophila requires the cell cycle regulators encoded by the genes, giant nuclei (gnu), plutonium (plu) and pan gu (png). Embryos lacking Gnu protein undergo DNA replication and centrosome proliferation without chromosome condensation or mitotic segregation. We have identified the gnu gene encoding a novel phosphoprotein dephosphorylated by Protein phosphatase 1 at egg activation. Gnu is normally expressed in the nurse cells and oocyte of the ovary and is degraded during the embryonic cleavage mitoses. Ovarian death and sterility result from gnu gain of function. gnu function requires the activity of pan gu and plu.

Key words: Drosophila melanogaster, Mitosis, DNA replication, Fertilization, Oogenesis, Protein phosphatase 1




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© The Company of Biologists Ltd 2003