|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
First published online August 18, 2003
doi: 10.1242/10.1242/dev.00673
1 Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
2 Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical
School, Boston, MA 02115, USA
* Author for correspondence (e-mail: tabin{at}genetics.med.harvard.edu)
Accepted 13 June 2003
During development neural crest cells give rise to a wide variety of specialized cell types in response to cytokines from surrounding tissues. Depending on the cranial-caudal level of their origin, different populations of neural crest cells exhibit differential competence to respond to these signals as exemplified by the unique ability of cranial neural crest to form skeletal cell types. We show that in addition to differences in whether they respond to particular signals, cranial neural crest cells differ dramatically from the trunk neural crest cells in how they respond to specific extracellular signals, such that under identical conditions the same signal induces dissimilar cell fate decisions in the two populations in vitro. Conversely, the same differentiated cell types are induced by different signals in the two populations. These in vitro differences in neural crest response are consistent with in vivo manipulations. We also provide evidence that these differences in responsiveness are modulated, at least in part, by differential expression of Hox genes within the neural crest.
Key words: Cranial neural crest, Trunk neural crest, Signaling, Differentiation, Chick
This article has been cited by other articles:
|
|
 |
|
  P. Leucht, J.-B. Kim, R. Amasha, A. W. James, S. Girod, and J. A. Helms Embryonic origin and Hox status determine progenitor cell fate during adult bone regeneration Development, September 1, 2008; 135(17): 2845 - 2854. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. W. Calloni, C. Glavieux-Pardanaud, N. M. Le Douarin, and E. Dupin Sonic Hedgehog promotes the development of multipotent neural crest progenitors endowed with both mesenchymal and neural potentials PNAS, December 11, 2007; 104(50): 19879 - 19884. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. F. Gilbert, G. Bender, E. Betters, M. Yin, and J. A. Cebra-Thomas The contribution of neural crest cells to the nuchal bone and plastron of the turtle shell Integr. Comp. Biol., September 1, 2007; 47(3): 401 - 408. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Billon, P. Iannarelli, M. C. Monteiro, C. Glavieux-Pardanaud, W. D. Richardson, N. Kessaris, C. Dani, and E. Dupin The generation of adipocytes by the neural crest Development, June 15, 2007; 134(12): 2283 - 2292. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. D. Pruett, T. V. Tkatchenko, L. Jave-Suarez, D. F. Jacobs, C. S. Potter, A. V. Tkatchenko, J. Schweizer, and A. Awgulewitsch Krtap16, Characterization of a New Hair Keratin-associated Protein (KAP) Gene Complex on Mouse Chromosome 16 and Evidence for Regulation by Hoxc13 J. Biol. Chem., December 3, 2004; 279(49): 51524 - 51533. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. M. Le Douarin, S. Creuzet, G. Couly, and E. Dupin Neural crest cell plasticity and its limits Development, October 1, 2004; 131(19): 4637 - 4650. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Trentin, C. Glavieux-Pardanaud, N. M. Le Douarin, and E. Dupin Self-renewal capacity is a widespread property of various types of neural crest precursor cells PNAS, March 30, 2004; 101(13): 4495 - 4500. [Abstract] [Full Text] [PDF]
|
|
