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doi: 10.1242/10.1242/dev.00270
1 Carnegie Institution of Washington, Department of Embryology, 115 W.
University Parkway, Baltimore, MD, 21210, USA
2 IGBMC, CNRS/INSERM/ULP, 1 rue Laurent Fries, BP10142, CU de Strasbourg, 67404
Illkirch cedex, France
* Author for correspondence (e-mail: halpern{at}ciwemb.edu)
Accepted 26 November 2002
The dorsal diencephalon (or epithalamus) of larval zebrafish displays distinct left-right asymmetries. The pineal complex consists of the pineal organ anlage and an unpaired, left-sided accessory organ – the parapineal. The neighboring brain nuclei, the left and right dorsal habenulae, show consistent differences in their size, density of neuropil and gene expression. Mutational analyses demonstrate a correlation between the left-right position of the parapineal and the laterality of the habenular nuclei. We show that selective ablation of the parapineal organ results in the loss of habenular asymmetry. The left-sided parapineal therefore influences the left-right identity of adjacent brain nuclei, indicating that laterality of the dorsal diencephalon arises in a step-wise fashion.
Key words: Habenula, Epithalamus, Epiphysis, Pineal organ, Brain laterality
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