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First published online 26 November 2003
doi: 10.1242/dev.00896
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1 Department of Biological Sciences, Stanford University, Stanford, CA 94305,
USA
2 Neurosciences Program, Stanford University, Stanford, CA 94305, USA
3 Department of Biology, University of Fribourg, CH-1700 Fribourg,
Switzerland
4 Institute of Molecular and Cellular Biosciences, University of Tokyo,
Japan
5 The Graduate University for Advanced Studies, Japan
Author for correspondence (e-mail:
lluo{at}stanford.edu)
Accepted 1 October 2003
In both insects and mammals, olfactory receptor neurons (ORNs) expressing
specific olfactory receptors converge their axons onto specific glomeruli,
creating a spatial map in the brain. We have previously shown that second
order projection neurons (PNs) in Drosophila are prespecified by
lineage and birth order to send their dendrites to one of 
50 glomeruli in
the antennal lobe. How can a given class of ORN axons match up with a given
class of PN dendrites? Here, we examine the cellular and developmental events
that lead to this wiring specificity. We find that, before ORN axon arrival,
PN dendrites have already created a prototypic map that resembles the adult
glomerular map, by virtue of their selective dendritic localization.
Positional cues that create this prototypic dendritic map do not appear to be
either from the residual larval olfactory system or from glial processes
within the antennal lobe. We propose instead that this prototypic map might
originate from both patterning information external to the developing antennal
lobe and interactions among PN dendrites.
Key words: Dendrites, Dendritic development, Antennal lobe, Projection neurons, Drosophila, Olfaction
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