|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
First published online 26 May 2004
doi: 10.1242/dev.01176
| |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Cincinnati Children’s Hospital Medical Center, Division of Developmental Biology and The Department of Pediatrics, University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229-3039, USA
Author for correspondence (e-mail:
aaron.zorn{at}chmcc.org)
Accepted 18 March 2004
Recent studies have led to a model of the molecular pathway that specifies the endoderm during vertebrate gastrulation. The HMG box transcription factor Sox17 is a key component of this pathway and is essential for endoderm formation; however, the molecular events controlled by Sox17 are largely unknown. We have identified several direct transcriptional targets of Sox17, including Foxa1 and Foxa2. We show that ß-catenin, a component of Wnt signaling pathway, physically interacts with Sox17 and potentiates its transcriptional activation of target genes. We identify a motif in the C terminus of Sox17, which is conserved in all the SoxF subfamily of Sox proteins, and this motif is required for the ability of Sox17 to both transactivate target genes and bind ß-catenin. Nuclear ß-catenin is present in endoderm cells of the gastrula, and depletion of ß-catenin from embryos results in a repression of Sox17 target genes. These data suggest that in a mechanism analogous to Tcf/Lef interacting with ß-catenin, Sox17 and ß-catenin interact to transcribe endodermal target genes.
Key words: Endoderm, Transcription, Sox17, ß-catenin, Foxa, Gata, Xenopus
This article has been cited by other articles:
|
|
 |
|
  L. Guo, D. Zhong, S. Lau, X. Liu, X.-Y. Dong, X. Sun, V. W. Yang, P. M. Vertino, C. S. Moreno, V. Varma, et al. Sox7 Is an Independent Checkpoint for {beta}-Catenin Function in Prostate and Colon Epithelial Cells Mol. Cancer Res., September 1, 2008; 6(9): 1421 - 1430. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. C. Hay, J. Fletcher, C. Payne, J. D. Terrace, R. C. J. Gallagher, J. Snoeys, J. R. Black, D. Wojtacha, K. Samuel, Z. Hannoun, et al. Highly efficient differentiation of hESCs to functional hepatic endoderm requires ActivinA and Wnt3a signaling PNAS, August 26, 2008; 105(34): 12301 - 12306. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. S. Patterson, R. C. Addis, M. J. Shamblott, and J. D. Gearhart SOX17 directly activates Zfp202 transcription during in vitro endoderm differentiation Physiol Genomics, August 14, 2008; 34(3): 277 - 284. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Chen, L. Shi, L. Zhang, R. Li, J. Liang, W. Yu, L. Sun, X. Yang, Y. Wang, Y. Zhang, et al. The Molecular Mechanism Governing the Oncogenic Potential of SOX2 in Breast Cancer J. Biol. Chem., June 27, 2008; 283(26): 17969 - 17978. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Chen, K. Hussain, M. Al-Ali, M. T. Dattani, P. Hindmarsh, P. M. Jones, and P. Marsh Neonatal and Late-Onset Diabetes Mellitus Caused by Failure of Pancreatic Development: Report of 4 More Cases and a Review of the Literature Pediatrics, June 1, 2008; 121(6): e1541 - e1547. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Kelberman, S. C. P. de Castro, S. Huang, J. A. Crolla, R. Palmer, J. W. Gregory, D. Taylor, L. Cavallo, M. F. Faienza, R. Fischetto, et al. SOX2 Plays a Critical Role in the Pituitary, Forebrain, and Eye during Human Embryonic Development J. Clin. Endocrinol. Metab., May 1, 2008; 93(5): 1865 - 1873. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Zhang, S. C. Glockner, M. Guo, E. O. Machida, D. H. Wang, H. Easwaran, L. Van Neste, J. G. Herman, K. E. Schuebel, D. N. Watkins, et al. Epigenetic Inactivation of the Canonical Wnt Antagonist SRY-Box Containing Gene 17 in Colorectal Cancer Cancer Res., April 15, 2008; 68(8): 2764 - 2772. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. B. Pearson, A. McCarthy, C. M.P. Collins, A. Ashworth, and A. R. Clarke Lkb1 Deficiency Causes Prostate Neoplasia in the Mouse Cancer Res., April 1, 2008; 68(7): 2223 - 2232. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Cermenati, S. Moleri, S. Cimbro, P. Corti, L. Del Giacco, R. Amodeo, E. Dejana, P. Koopman, F. Cotelli, and M. Beltrame Sox18 and Sox7 play redundant roles in vascular development Blood, March 1, 2008; 111(5): 2657 - 2666. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Wohrle, B. Wallmen, and A. Hecht Differential Control of Wnt Target Genes Involves Epigenetic Mechanisms and Selective Promoter Occupancy by T-Cell Factors Mol. Cell. Biol., December 1, 2007; 27(23): 8164 - 8177. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Sinner, J. J. Kordich, J. R. Spence, R. Opoka, S. Rankin, S.-C. J. Lin, D. Jonatan, A. M. Zorn, and J. M. Wells Sox17 and Sox4 Differentially Regulate {beta}-Catenin/T-Cell Factor Activity and Proliferation of Colon Carcinoma Cells Mol. Cell. Biol., November 15, 2007; 27(22): 7802 - 7815. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Schiedlmeier, A. C. Santos, A. Ribeiro, N. Moncaut, D. Lesinski, H. Auer, K. Kornacker, W. Ostertag, C. Baum, M. Mallo, et al. HOXB4's road map to stem cell expansion PNAS, October 23, 2007; 104(43): 16952 - 16957. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. A. McLin, S. A. Rankin, and A. M. Zorn Repression of Wnt/{beta}-catenin signaling in the anterior endoderm is essential for liver and pancreas development Development, June 15, 2007; 134(12): 2207 - 2217. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Liu, M. Asakura, H. Inoue, T. Nakamura, M. Sano, Z. Niu, M. Chen, R. J. Schwartz, and M. D. Schneider Sox17 is essential for the specification of cardiac mesoderm in embryonic stem cells PNAS, March 6, 2007; 104(10): 3859 - 3864. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. T. Chao, W. M. Jones, and A. Bejsovec The HMG-box transcription factor SoxNeuro acts with Tcf to control Wg/Wnt signaling activity Development, March 1, 2007; 134(5): 989 - 997. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Maeda, V. Dave, and J. A. Whitsett Transcriptional Control of Lung Morphogenesis Physiol Rev, January 1, 2007; 87(1): 219 - 244. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Schepsky, K. Bruser, G. J. Gunnarsson, J. Goodall, J. H. Hallsson, C. R. Goding, E. Steingrimsson, and A. Hecht The Microphthalmia-Associated Transcription Factor Mitf Interacts with {beta}-Catenin To Determine Target Gene Expression Mol. Cell. Biol., December 1, 2006; 26(23): 8914 - 8927. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Sohn, J. Natale, L.-J. Chew, S. Belachew, Y. Cheng, A. Aguirre, J. Lytle, B. Nait-Oumesmar, C. Kerninon, M. Kanai-Azuma, et al. Identification of Sox17 as a transcription factor that regulates oligodendrocyte development. J. Neurosci., September 20, 2006; 26(38): 9722 - 9735. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. L. Zamparini, T. Watts, C. E. Gardner, S. R. Tomlinson, G. I. Johnston, and J. M. Brickman Hex acts with {beta}-catenin to regulate anteroposterior patterning via a Groucho-related co-repressor and Nodal Development, September 15, 2006; 133(18): 3709 - 3722. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Matsui, M. Kanai-Azuma, K. Hara, S. Matoba, R. Hiramatsu, H. Kawakami, M. Kurohmaru, P. Koopman, and Y. Kanai Redundant roles of Sox17 and Sox18 in postnatal angiogenesis in mice J. Cell Sci., September 1, 2006; 119(17): 3513 - 3526. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Sinner, P. Kirilenko, S. Rankin, E. Wei, L. Howard, M. Kofron, J. Heasman, H. R. Woodland, and A. M. Zorn Global analysis of the transcriptional network controlling Xenopus endoderm formation. Development, May 1, 2006; 133(10): 1955 - 1966. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Liu, S. Ramachandran, M. Ali Seyed, C. D. Scharer, N. Laycock, W. B. Dalton, H. Williams, S. Karanam, M. W. Datta, D. L. Jaye, et al. Sex-determining region y box 4 is a transforming oncogene in human prostate cancer cells. Cancer Res., April 15, 2006; 66(8): 4011 - 4019. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K.-S. Park, J. M. Wells, A. M. Zorn, S. E. Wert, V. E. Laubach, L. G. Fernandez, and J. A. Whitsett Transdifferentiation of Ciliated Cells during Repair of the Respiratory Epithelium Am. J. Respir. Cell Mol. Biol., February 1, 2006; 34(2): 151 - 157. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. L. Mucenski, J. M. Nation, A. R. Thitoff, V. Besnard, Y. Xu, S. E. Wert, N. Harada, M. M. Taketo, M. T. Stahlman, and J. A. Whitsett {beta}-Catenin regulates differentiation of respiratory epithelial cells in vivo Am J Physiol Lung Cell Mol Physiol, December 1, 2005; 289(6): L971 - L979. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Skottman, M. Mikkola, K. Lundin, C. Olsson, A.-M. Stromberg, T. Tuuri, T. Otonkoski, O. Hovatta, and R. Lahesmaa Gene Expression Signatures of Seven Individual Human Embryonic Stem Cell Lines Stem Cells, September 1, 2005; 23(9): 1343 - 1356. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. E. Reintsch, A. Habring-Mueller, R. W. Wang, A. Schohl, and F. Fagotto {beta}-Catenin controls cell sorting at the notochord-somite boundary independently of cadherin-mediated adhesion J. Cell Biol., August 15, 2005; 170(4): 675 - 686. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Gao, K. Ishii, J. Mirosevich, S. Kuwajima, S. R. Oppenheimer, R. L. Roberts, M. Jiang, X. Yu, S. B. Shappell, R. M. Caprioli, et al. Forkhead box A1 regulates prostate ductal morphogenesis and promotes epithelial cell maturation Development, August 1, 2005; 132(15): 3431 - 3443. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. DasGupta, A. Kaykas, R. T. Moon, and N. Perrimon Functional Genomic Analysis of the Wnt-Wingless Signaling Pathway Science, May 6, 2005; 308(5723): 826 - 833. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Kleber, H.-Y. Lee, H. Wurdak, J. Buchstaller, M. M. Riccomagno, L. M. Ittner, U. Suter, D. J. Epstein, and L. Sommer Neural crest stem cell maintenance by combinatorial Wnt and BMP signaling J. Cell Biol., April 25, 2005; 169(2): 309 - 320. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Gregorieff and H. Clevers Wnt signaling in the intestinal epithelium: from endoderm to cancer Genes & Dev., April 15, 2005; 19(8): 877 - 890. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. G. Giresi, E. J. Stevenson, J. Theilhaber, A. Koncarevic, J. Parkington, R. A. Fielding, and S. C. Kandarian Identification of a molecular signature of sarcopenia Physiol Genomics, April 14, 2005; 21(2): 253 - 263. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Mansukhani, D. Ambrosetti, G. Holmes, L. Cornivelli, and C. Basilico Sox2 induction by FGF and FGFR2 activating mutations inhibits Wnt signaling and osteoblast differentiation J. Cell Biol., March 28, 2005; 168(7): 1065 - 1076. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Chiao, J. Leonard, K. Dickinson, and J. C. Baker High-throughput functional screen of mouse gastrula cDNA libraries reveals new components of endoderm and mesoderm specification Genome Res., January 1, 2005; 15(1): 44 - 53. [Abstract] [Full Text] [PDF]
|
|
