spacer gif spacer gif spacer gif spacer gif ARCHIVE ANNOUNCEMENT! spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

First published online August 2, 2004
doi: 10.1242/10.1242/dev.01268

Development 131, 3907-3920 (2004)
Published by The Company of Biologists 2004
This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Related articles in Development
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Oliver, E. R.
Right arrow Articles by Glaser, T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Oliver, E. R.
Right arrow Articles by Glaser, T.

Ribosomal protein L24 defect in Belly spot and tail (Bst), a mouse Minute

Edward R. Oliver1, Thomas L. Saunders2, Susan A. Tarlé2 and Tom Glaser1,2,*

1 Department of Human Genetics, University of Michigan Medical School, Ann Arbor, MI 48109, USA
2 Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA

* Author for correspondence (e-mail: tglaser{at}umich.edu)

Accepted 12 May 2004

Ribosomal protein mutations, termed Minutes, have been instrumental in studying the coordination of cell and tissue growth in Drosophila. Although abundant in flies, equivalent defects in mammals are relatively unknown. Belly spot and tail (Bst) is a semidominant mouse mutation that disrupts pigmentation, somitogenesis and retinal cell fate determination. Here, we identify Bst as a deletion within the Rpl24 riboprotein gene. Bst significantly impairs Rpl24 splicing and ribosome biogenesis. Bst/+ cells have decreased rates of protein synthesis and proliferation, and are outcompeted by wild-type cells in C57BLKS{leftrightarrow}ROSA26 chimeras. Bacterial artificial chromosome (BAC) and cDNA transgenes correct the mutant phenotypes. Our findings establish Bst as a mouse Minute and provide the first detailed characterization of a mammalian ribosomal protein mutation.

Key words: Mouse, Genetics, Minute, Ribosome, Cell cycle, Retina, Bst


Related articles in Development:

Ribosomal insights from Minute mice

Development 2004 131: e1602. [Full Text]  



This article has been cited by other articles:


Home page
 Hum Mol GenetHome page
T. Uechi, Y. Nakajima, A. Chakraborty, H. Torihara, S. Higa, and N. Kenmochi
Deficiency of ribosomal protein S19 during early embryogenesis leads to reduction of erythrocytes in a zebrafish model of Diamond-Blackfan anemia
Hum. Mol. Genet., October 15, 2008; 17(20): 3204 - 3211.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
J. E. Farrar, M. Nater, E. Caywood, M. A. McDevitt, J. Kowalski, C. M. Takemoto, C. C. Talbot Jr, P. Meltzer, D. Esposito, A. H. Beggs, et al.
Abnormalities of the large ribosomal subunit protein, Rpl35a, in Diamond-Blackfan anemia
Blood, September 1, 2008; 112(5): 1582 - 1592.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
A. W. MacInnes, A. Amsterdam, C. A. Whittaker, N. Hopkins, and J. A. Lees
Loss of p53 synthesis in zebrafish tumors with ribosomal protein gene mutations
PNAS, July 29, 2008; 105(30): 10408 - 10413.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
N. E. Baker and W. Li
Cell Competition and Its Possible Relation to Cancer
Cancer Res., July 15, 2008; 68(14): 5505 - 5507.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
Y. Yao, Q. Ling, H. Wang, and H. Huang
Ribosomal proteins promote leaf adaxial identity
Development, April 1, 2008; 135(7): 1325 - 1334.
[Abstract] [Full Text] [PDF]

Home page
 Stem CellsHome page
K. Miyake, T. Utsugisawa, J. Flygare, T. Kiefer, I. Hamaguchi, J. Richter, and S. Karlsson
Ribosomal Protein S19 Deficiency Leads to Reduced Proliferation and Increased Apoptosis but Does Not Affect Terminal Erythroid Differentiation in a Cell Line Model of Diamond-Blackfan Anemia
Stem Cells, February 1, 2008; 26(2): 323 - 329.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
T. Pederson
Ribosomal protein mutations in Diamond-Blackfan anemia: might they operate upstream from protein synthesis?
FASEB J, November 1, 2007; 21(13): 3442 - 3445.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
K. A. Bernstein, F. Bleichert, J. M. Bean, F. R. Cross, and S. J. Baserga
Ribosome Biogenesis Is Sensed at the Start Cell Cycle Checkpoint
Mol. Biol. Cell, March 1, 2007; 18(3): 953 - 964.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
L. Yu, L. P. Castillo, S. Mnaimneh, T. R. Hughes, and G. W. Brown
A Survey of Essential Gene Function in the Yeast Cell Division Cycle
Mol. Biol. Cell, November 1, 2006; 17(11): 4736 - 4747.
[Abstract] [Full Text] [PDF]

Home page
 Plant CellHome page
T. Nishimura, T. Wada, K. T. Yamamoto, and K. Okada
The Arabidopsis STV1 Protein, Responsible for Translation Reinitiation, Is Required for Auxin-Mediated Gynoecium Patterning
PLANT CELL, November 1, 2005; 17(11): 2940 - 2953.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
P. Gallant
Myc, Cell Competition, and Compensatory Proliferation
Cancer Res., August 1, 2005; 65(15): 6485 - 6487.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
D. Rudra and J. R. Warner
What better measure than ribosome synthesis?
Genes & Dev., October 15, 2004; 18(20): 2431 - 2436.
[Full Text] [PDF]


© The Company of Biologists Ltd 2004