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First published online 11 August 2004
doi: 10.1242/dev.01317
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1 Brookdale Department of Molecular, Cell and Developmental Biology, Mount Sinai
School of Medicine, One Gustave L. Levy Place, New York, NY 10029, USA
2 Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauer
Strasse 108, 01307 Dresden, Germany
* Author for correspondence (e-mail: marek.mlodzik{at}mssm.edu)
Accepted 17 June 2004
Planar cell polarity (PCP) in the Drosophila eye is established by the distinct fate specifications of photoreceptors R3 and R4, and is regulated by the Frizzled (Fz)/PCP signaling pathway. Before the PCP proteins become asymmetrically localized to opposite poles of the cell in response to Fz/PCP signaling, they are uniformly apically colocalized. Little is known about how the apical localization is maintained. We provide evidence that the PCP protein Diego (Dgo) promotes the maintenance of apical localization of Flamingo (Fmi), an atypical Cadherin-family member, which itself is required for the apical localization of the other PCP factors. This function of Dgo is redundant with Prickle (Pk) and Strabismus (Stbm), and only appreciable in double mutant tissue. We show that the initial membrane association of Dgo depends on Fz, and that Dgo physically interacts with Stbm and Pk through its Ankyrin repeats, providing evidence for a PCP multiprotein complex. These interactions suggest a positive feedback loop initiated by Fz that results in the apical maintenance of other PCP factors through Fmi.
Key words: Drosophila, Eye, PCP, Vang, pk, Stbm
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