|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
First published online October 27, 2004
doi: 10.1242/10.1242/dev.01451
Review |
1 Monash Institute of Reproduction and Development, Monash University, Clayton,
Victoria, Australia
2 Department of Physiology, Monash University, Clayton, Victoria,
Australia
* Author for correspondence (e-mail: martin.pera{at}med.monash.edu.au)
SUMMARY
It is widely anticipated that human embryonic stem (ES) cells will serve as an experimental model for studying early development in our species, and, conversely, that studies of development in model systems, the mouse in particular, will inform our efforts to manipulate human stem cells in vitro. A comparison of primate and mouse ES cells suggests that a common underlying blueprint for the pluripotent state has undergone significant species-specific modification. As we discuss here, technical advances in the propagation and manipulation of human ES cells have improved our understanding of their growth and differentiation, providing the potential to investigate early human development and to develop new clinical therapies.
This article has been cited by other articles:
|
|
 |
|
  B. Valamehr, S. J. Jonas, J. Polleux, R. Qiao, S. Guo, E. H. Gschweng, B. Stiles, K. Kam, T.-J. M. Luo, O. N. Witte, et al. Hydrophobic surfaces for enhanced differentiation of embryonic stem cell-derived embryoid bodies PNAS, September 23, 2008; 105(38): 14459 - 14464. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. M. Cameron, F. Harding, W.-S. Hu, and D. S. Kaufman Activation of Hypoxic Response in Human Embryonic Stem Cell-Derived Embryoid Bodies Experimental Biology and Medicine, August 1, 2008; 233(8): 1044 - 1057. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Chiao, M. Elazar, Y. Xing, A. Xiong, M. Kmet, M. T. Millan, J. S. Glenn, W. H. Wong, and J. Baker Isolation and Transcriptional Profiling of Purified Hepatic Cells Derived from Human Embryonic Stem Cells Stem Cells, August 1, 2008; 26(8): 2032 - 2041. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. F. Cole, S. E. Johnstone, J. J. Newman, M. H. Kagey, and R. A. Young Tcf3 is an integral component of the core regulatory circuitry of embryonic stem cells Genes & Dev., March 15, 2008; 22(6): 746 - 755. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Zhang, J. Li, Z. Tan, C. Wang, T. Liu, L. Chen, J. Yong, W. Jiang, X. Sun, L. Du, et al. Short-term BMP-4 treatment initiates mesoderm induction in human embryonic stem cells Blood, February 15, 2008; 111(4): 1933 - 1941. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Li, C. Zhou, C. Liu, Q. Mai, and G. Zhuang Bulk vitrification of human embryonic stem cells Hum. Reprod., February 1, 2008; 23(2): 358 - 364. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. A. Koch, P. Geraldes, and J. L. Platt Immunosuppression by Embryonic Stem Cells Stem Cells, January 1, 2008; 26(1): 89 - 98. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Hayashi, M. K. Furue, T. Okamoto, K. Ohnuma, Y. Myoishi, Y. Fukuhara, T. Abe, J. D. Sato, R.-I. Hata, and M. Asashima Integrins Regulate Mouse Embryonic Stem Cell Self-Renewal Stem Cells, December 1, 2007; 25(12): 3005 - 3015. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Wilber, J. L. Linehan, X. Tian, P. S. Woll, J. K. Morris, L. R. Belur, R. S. McIvor, and D. S. Kaufman Efficient and Stable Transgene Expression in Human Embryonic Stem Cells Using Transposon-Mediated Gene Transfer Stem Cells, November 1, 2007; 25(11): 2919 - 2927. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. S. Vieyra and M. A. Goodell Pluripotentiality and Conditional Transgene Regulation in Human Embryonic Stem Cells Expressing Insulated Tetracycline-ON Transactivator Stem Cells, October 1, 2007; 25(10): 2559 - 2566. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Tomescot, J. Leschik, V. Bellamy, G. Dubois, E. Messas, P. Bruneval, M. Desnos, A. A. Hagege, M. Amit, J. Itskovitz, et al. Differentiation In Vivo of Cardiac Committed Human Embryonic Stem Cells in Postmyocardial Infarcted Rats Stem Cells, September 1, 2007; 25(9): 2200 - 2205. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. E. Gargett Review Article: Stem Cells in Human Reproduction Reproductive Sciences, July 1, 2007; 14(5): 405 - 424. [Abstract] [PDF]
|
|
|
|
|
|
A. Guhr, A. Kurtz, K. Friedgen, and P. Loser Current State of Human Embryonic Stem Cell Research: An Overview of Cell Lines and Their Use in Experimental Work Stem Cells, October 1, 2006; 24(10): 2187 - 2191. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Van Hoof, R. Passier, D. Ward-Van Oostwaard, M. W. H. Pinkse, A. J. R. Heck, C. L. Mummery, and J. Krijgsveld A Quest for Human and Mouse Embryonic Stem Cell-specific Proteins Mol. Cell. Proteomics, July 1, 2006; 5(7): 1261 - 1273. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Richards, S.-P. Tan, W.-K. Chan, and A. Bongso Reverse Serial Analysis of Gene Expression (SAGE) Characterization of Orphan SAGE Tags from Human Embryonic Stem Cells Identifies the Presence of Novel Transcripts and Antisense Transcription of Key Pluripotency Genes Stem Cells, May 1, 2006; 24(5): 1162 - 1173. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Tian, P. S. Woll, J. K. Morris, J. L. Linehan, and D. S. Kaufman Hematopoietic Engraftment of Human Embryonic Stem Cell-Derived Cells Is Regulated by Recipient Innate Immunity Stem Cells, May 1, 2006; 24(5): 1370 - 1380. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Trounson The Production and Directed Differentiation of Human Embryonic Stem Cells Endocr. Rev., April 1, 2006; 27(2): 208 - 219. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Poon, F. Clermont, M. T. Firpo, and R. J. Akhurst TGF{beta} inhibition of yolk-sac-like differentiation of human embryonic stem-cell-derived embryoid bodies illustrates differences between early mouse and human development J. Cell Sci., February 15, 2006; 119(4): 759 - 768. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. L. Olsen, D. L. Stachura, and M. J. Weiss Designer blood: creating hematopoietic lineages from embryonic stem cells Blood, February 15, 2006; 107(4): 1265 - 1275. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Iuchi, S. Dabelsteen, K. Easley, J. G. Rheinwald, and H. Green Immortalized keratinocyte lines derived from human embryonic stem cells PNAS, February 7, 2006; 103(6): 1792 - 1797. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Vallier, M. Alexander, and R. A. Pedersen Activin/Nodal and FGF pathways cooperate to maintain pluripotency of human embryonic stem cells J. Cell Sci., October 1, 2005; 118(19): 4495 - 4509. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Leri, J. Kajstura, and P. Anversa Cardiac Stem Cells and Mechanisms of Myocardial Regeneration Physiol Rev, October 1, 2005; 85(4): 1373 - 1416. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Kameda and J. A. Thomson Human ERas Gene Has an Upstream Premature Polyadenylation Signal That Results in a Truncated, Noncoding Transcript Stem Cells, October 1, 2005; 23(10): 1535 - 1540. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. E. Wiblin, W. Cui, A. J. Clark, and W. A. Bickmore Distinctive nuclear organisation of centromeres and regions involved in pluripotency in human embryonic stem cells J. Cell Sci., September 1, 2005; 118(17): 3861 - 3868. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Keller Embryonic stem cell differentiation: emergence of a new era in biology and medicine Genes & Dev., May 15, 2005; 19(10): 1129 - 1155. [Abstract] [Full Text] [PDF]
|
|
