|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
First published online December 8, 2004
doi: 10.1242/10.1242/dev.01539
Review |
1 Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
2 Department of Biology, Massachusetts Institute of Technology, Cambridge, MA
02142, USA
Author for correspondence (e-mail:
rebay{at}wi.mit.edu)
SUMMARY
Context-specific integration of information received from the Notch, Transforming growth factor ß, Wingless/Wnt, Hedgehog and Epidermal growth factor receptor signaling pathways sets the stage for deployment of the retinal determination gene network (RDGN), a group of transcription factors that collectively directs the formation of the eye and other tissues. Recent investigations have revealed how these transcription factors are regulated by their interactions with each other and with effectors of the above signaling pathways. Further study of the RDGN may provide insights into how common cues can generate context-specific responses, a key aspect of developmental regulation that remains poorly understood.
This article has been cited by other articles:
|
|
 |
|
  T. Hayashi, C. Xu, and R. W. Carthew Cell-type-specific transcription of prospero is controlled by combinatorial signaling in the Drosophila eye Development, August 15, 2008; 135(16): 2787 - 2796. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Kozmik, J. Ruzickova, K. Jonasova, Y. Matsumoto, P. Vopalensky, I. Kozmikova, H. Strnad, S. Kawamura, J. Piatigorsky, V. Paces, et al. From the Cover: Assembly of the cnidarian camera-type eye from vertebrate-like components PNAS, July 1, 2008; 105(26): 8989 - 8993. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Clements, Z. Lu, W. J. Gehring, I. A. Meinertzhagen, and P. Callaerts Central projections of photoreceptor axons originating from ectopic eyes in Drosophila PNAS, July 1, 2008; 105(26): 8968 - 8973. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Mu, X. Fu, P. D. Beremand, T. L. Thomas, and W. H. Klein Gene-regulation logic in retinal ganglion cell development: Isl1 defines a critical branch distinct from but overlapping with Pou4f2 PNAS, May 13, 2008; 105(19): 6942 - 6947. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Hayward, T. Kalmar, and A. Martinez Arias Wnt/Notch signalling and information processing during development Development, February 1, 2008; 135(3): 411 - 424. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Schlosser How old genes make a new head: redeployment of Six and Eya genes during the evolution of vertebrate cranial placodes Integr. Comp. Biol., September 1, 2007; 47(3): 343 - 359. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Zhu, A. S. Gleiberman, and M. G. Rosenfeld Molecular Physiology of Pituitary Development: Signaling and Transcriptional Networks Physiol Rev, July 1, 2007; 87(3): 933 - 963. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Vooijs, C.-T. Ong, B. Hadland, S. Huppert, Z. Liu, J. Korving, M. van den Born, T. Stappenbeck, Y. Wu, H. Clevers, et al. Mapping the consequence of Notch1 proteolysis in vivo with NIP-CRE Development, February 1, 2007; 134(3): 535 - 544. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Zhang, S. Ranade, C. Q. Cai, C. Clouser, and F. Pignoni Direct control of neurogenesis by selector factors in the fly eye: regulation of atonal by Ey and So Development, December 15, 2006; 133(24): 4881 - 4889. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Singh, X. Shi, and K.-W. Choi Lobe and Serrate are required for cell survival during early eye development in Drosophila. Development, December 1, 2006; 133(23): 4771 - 4781. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Tang and D. Goldman Activity-dependent gene regulation in skeletal muscle is mediated by a histone deacetylase (HDAC)-Dach2-myogenin signal transduction cascade PNAS, November 7, 2006; 103(45): 16977 - 16982. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. B. Mahoney, A. L. Parks, D. A. Ruddy, S. Y. K. Tiong, H. Esengil, A. C. Phan, P. Philandrinos, C. G. Winter, R. Chatterjee, K. Huppert, et al. Presenilin-Based Genetic Screens in Drosophila melanogaster Identify Novel Notch Pathway Modifiers Genetics, April 1, 2006; 172(4): 2309 - 2324. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. H. Davidson and D. H. Erwin Gene Regulatory Networks and the Evolution of Animal Body Plans Science, February 10, 2006; 311(5762): 796 - 800. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. J. Tapscott The circuitry of a master switch: Myod and the regulation of skeletal muscle gene transcription Development, June 15, 2005; 132(12): 2685 - 2695. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Mutsuddi, B. Chaffee, J. Cassidy, S. J. Silver, T. L. Tootle, and I. Rebay Using Drosophila to Decipher How Mutations Associated With Human Branchio-Oto-Renal Syndrome and Optical Defects Compromise the Protein Tyrosine Phosphatase and Transcriptional Functions of Eyes Absent Genetics, June 1, 2005; 170(2): 687 - 695. [Abstract] [Full Text] [PDF]
|
|
