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First published online May 12, 2005
doi: 10.1242/10.1242/dev.01812

Development 132, 2503-2512 (2005)
Published by The Company of Biologists 2005
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Review

Structure and function of the notochord: an essential organ for chordate development

Derek L. Stemple

Vertebrate Development and Genetics, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK

e-mail: ds4{at}sanger.ac.uk

SUMMARY

The notochord is the defining structure of the chordates, and has essential roles in vertebrate development. It serves as a source of midline signals that pattern surrounding tissues and as a major skeletal element of the developing embryo. Genetic and embryological studies over the past decade have informed us about the development and function of the notochord. In this review, I discuss the embryonic origin, signalling roles and ultimate fate of the notochord, with an emphasis on structural aspects of notochord biology.




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