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First published online 4 May 2005
doi: 10.1242/dev.01852

Development 132, 2623-2632 (2005)
Published by The Company of Biologists 2005
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The boundary cap: a source of neural crest stem cells that generate multiple sensory neuron subtypes

Jens Hjerling-Leffler1, Frédéric Marmigère1, Mikael Heglind2, Anna Cederberg2, Martin Koltzenburg3, Sven Enerbäck2 and Patrik Ernfors1,*

1 Unit of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 171 77 Stockholm, Sweden
2 Unit of Medical Genetics Department of Medical Biochemistry Göteborg University, 405 30 Göteborg, Sweden
3 Institute of Child Health, University College London, London WC1N 1EH, UK

* Author for correspondence (e-mail: patrik.ernfors{at}mbb.ki.se)

Accepted 16 April 2005

The boundary cap (BC) is a transient neural crest-derived group of cells located at the dorsal root entry zone (DREZ) that have been shown to differentiate into sensory neurons and glia in vivo. We find that when placed in culture, BC cells self-renew, show multipotency in clonal cultures and express neural crest stem cell (NCSCs) markers. Unlike sciatic nerve NCSCs, the BC-NCSC (bNCSCs) generates sensory neurons upon differentiation. The bNCSCs constitute a common source of cells for functionally diverse types of neurons, as a single bNCSC can give rise to several types of nociceptive and thermoreceptive sensory neurons. Our data suggests that BC cells comprise a source of multipotent sensory specified stem cells that persist throughout embryogenesis.

Key words: Mouse, Peripheral nervous system, Migration, Fkh3, Foxs1




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[Abstract] [Full Text] [PDF]


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