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First published online 23 March 2005
doi: 10.1242/dev.01783

Development 132, 2023-2033 (2005)
Published by The Company of Biologists 2005
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Shh-dependent formation of the ZLI is opposed by signals from the dorsal diencephalon

Lori M. Zeltser

Department of Biochemistry and Molecular Biophysics, Columbia University, 701 West 168th Street, New York, NY 10032, USA

e-mail: lz146{at}columbia.edu

Accepted 11 February 2005

The zona limitans intrathalamica (ZLI) is located at the border between the prospective ventral thalamus and dorsal thalamus, and functions as a diencephalic signaling center. Little is known about the mechanism controlling ZLI formation. Using a combination of fate-mapping studies and in vitro assays, I show that the differentiation of the ZLI from progenitor cells in the alar plate is initiated by a Shh-dependent signal from the basal plate. The subsequent dorsal progression of ZLI differentiation requires ongoing Shh signaling, and is constrained by inhibitory factors derived from the dorsal diencephalon. These studies demonstrate that self-organizing signals from the basal plate regulate the formation of a potential patterning center in the ZLI in an orthogonal orientation in the alar plate, and thus create the potential for coordinated thalamic patterning in two dimensions.

Key words: Forebrain, Diencephalon, Signaling center, Shh, Chick




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© The Company of Biologists Ltd 2005