|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
First published online October 12, 2006
doi: 10.1242/10.1242/dev.02596
1 Department of Biochemistry, Dartmouth Medical School, Hanover, NH 03755,
USA.
2 Department of Anatomy, 1300 University Avenue, University of Wisconsin-Madison
School of Medicine and Public Health, Madison, WI 53706, USA.
Authors for correspondence (e-mail:
nancy.speck{at}dartmouth.edu;
kdowns{at}facstaff.wisc.edu)
Accepted 25 August 2006
The chorio-allantoic placenta forms through the fusion of the allantois (progenitor tissue of the umbilical cord), with the chorionic plate. The murine placenta contains high levels of hematopoietic stem cells, and is therefore a stem cell niche. However, it is not known whether the placenta is a site of hematopoietic cell emergence, or whether hematopoietic cells originate from other sites in the conceptus and then colonize the placenta. Here, we show that the allantois and chorion, isolated prior to the establishment of circulation, have the potential to give rise to myeloid and definitive erythroid cells following explant culture. We further show that the hematopoietic potential of the allantois and chorion does not require their union, indicating that it is an intrinsic property of these tissues. These results suggest that the placenta is not only a niche for, but also a source of, hematopoietic cells.
Key words: Placenta, Allantois, Chorion, Hematopoiesis, Mouse
Related articles in Development:
This article has been cited by other articles:
|
|
 |
|
  E. Dzierzak and A. Medvinsky The discovery of a source of adult hematopoietic cells in the embryo Development, July 15, 2008; 135(14): 2343 - 2346. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. C. Dubois, C. Adolphe, A. Ehninger, R. A. Wang, E. J. Robertson, and A. Trumpp Placental rescue reveals a sole requirement for c-Myc in embryonic erythroblast survival and hematopoietic stem cell function Development, July 15, 2008; 135(14): 2455 - 2465. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Katsuno, K. Umeda, T. Matsui, M. Hata, A. Tamura, M. Itoh, K. Takeuchi, T. Fujimori, Y.-i. Nabeshima, T. Noda, et al. Deficiency of Zonula Occludens-1 Causes Embryonic Lethal Phenotype Associated with Defected Yolk Sac Angiogenesis and Apoptosis of Embryonic Cells Mol. Biol. Cell, June 1, 2008; 19(6): 2465 - 2475. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Y. Bertrand, A. D. Kim, S. Teng, and D. Traver CD41+ cmyb+ precursors colonize the zebrafish pronephros by a novel migration route to initiate adult hematopoiesis Development, May 15, 2008; 135(10): 1853 - 1862. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. T. Lux, M. Yoshimoto, K. McGrath, S. J. Conway, J. Palis, and M. C. Yoder All primitive and definitive hematopoietic progenitor cells emerging before E10 in the mouse embryo are products of the yolk sac Blood, April 1, 2008; 111(7): 3435 - 3438. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. Parolini, F. Alviano, G. P. Bagnara, G. Bilic, H.-J. Buhring, M. Evangelista, S. Hennerbichler, B. Liu, M. Magatti, N. Mao, et al. Concise Review: Isolation and Characterization of Cells from Human Term Placenta: Outcome of the First International Workshop on Placenta Derived Stem Cells Stem Cells, February 1, 2008; 26(2): 300 - 311. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. T. Nottingham, A. Jarratt, M. Burgess, C. L. Speck, J.-F. Cheng, S. Prabhakar, E. M. Rubin, P.-S. Li, J. Sloane-Stanley, J. Kong-a-San, et al. Runx1-mediated hematopoietic stem-cell emergence is controlled by a Gata/Ets/SCL-regulated enhancer Blood, December 15, 2007; 110(13): 4188 - 4197. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Y. Bertrand, A. D. Kim, E. P. Violette, D. L. Stachura, J. L. Cisson, and D. Traver Definitive hematopoiesis initiates through a committed erythromyeloid progenitor in the zebrafish embryo Development, December 1, 2007; 134(23): 4147 - 4156. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Astorga and P. Carlsson Hedgehog induction of murine vasculogenesis is mediated by Foxf1 and Bmp4 Development, October 15, 2007; 134(20): 3753 - 3761. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Schenke-Layland, E. Angelis, K. E. Rhodes, S. Heydarkhan-Hagvall, H. K. Mikkola, and W. R. MacLellan Collagen IV Induces Trophoectoderm Differentiation of Mouse Embryonic Stem Cells Stem Cells, June 1, 2007; 25(6): 1529 - 1538. [Abstract] [Full Text] [PDF]
|
|
