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First published online January 12, 2006
doi: 10.1242/10.1242/dev.02240
1 Graduate Program in Structural Computational Biology and Molecular Biophysics,
Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.
2 Department of Molecular and Human Genetics, Baylor College of Medicine, One
Baylor Plaza, Houston, TX 77030, USA.
3 Faculty of Life Sciences, Michael Smith Building, University of Manchester,
Oxford Road, Manchester M13 9PT, UK.
* Authors for correspondence (e-mail: christopher.thompson{at}man.ac.uk and gadi{at}bcm.tmc.edu)
Accepted 24 November 2005
The signalling molecule DIF-1 is required for normal cell fate choice and patterning in Dictyostelium. To understand how these developmental processes are regulated will require knowledge of how cells receive and respond to the DIF-1 signal. Previously, we have described a bZIP transcription factor, DimA, which is required for cells to respond to DIF-1. However, it was unknown whether DimA activity is required to activate the DIF response pathway in certain cells or is a component of the response pathway itself. In this study, we describe the identification of a DimA-related bZIP transcription factor, DimB. Rapid changes in the subcellular localisation of both DimA and DimB in response to DIF-1 suggest that they are directly downstream of the DIF-1 signal. Genetic and biochemical interactions between DimA and DimB provides evidence that their ability to regulate diverse targets in response to DIF-1 is partly due to their ability to form homo- and heterodimeric complexes. DimA and DimB are therefore direct regulators of cellular responses to DIF-1.
Key words: Dictyostelium, DIF-1, bZIP, DimB
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