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First published online 3 January 2007
doi: 10.1242/dev.02739

Development 134, 503-513 (2007)
Published by The Company of Biologists 2007
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Wnt11/ß-catenin signaling in both oocytes and early embryos acts through LRP6-mediated regulation of axin

Matt Kofron1, Bilge Birsoy1, Douglas Houston2, Qinghua Tao1, Christopher Wylie1 and Janet Heasman1,*

1 Division of Developmental Biology, Cincinnati Children's Research Foundation, 3333 Burnet Avenue, Cincinnati, OH 45229-3039, USA.
2 Department of Biological Sciences, The University of Iowa, 257 Biology Building, Iowa City, IA 52242-1324, USA.

* Author for correspondence (e-mail: heabq9{at}chmcc.org)

Accepted 14 November 2006

Current models of canonical Wnt signaling assume that a pathway is active if ß-catenin becomes nuclearly localized and Wnt target genes are transcribed. We show that, in Xenopus, maternal LRP6 is essential in such a pathway, playing a pivotal role in causing expression of the organizer genes siamois and Xnr3, and in establishing the dorsal axis. We provide evidence that LRP6 acts by degrading axin protein during the early cleavage stage of development. In the full-grown oocyte, before maturation, we find that axin levels are also regulated by Wnt11 and LRP6. In the oocyte, Wnt11 and/or LRP6 regulates axin to maintain ß-catenin at a low level, while in the embryo, asymmetrical Wnt11/LRP6 signaling stabilizes ß-catenin and enriches it on the dorsal side. This suggests that canonical Wnt signaling may not exist in simple off or on states, but may also include a third, steady-state, modality.

Key words: Xenopus, ß-catenin, Wnt11, LRP6, Axis formation


Related articles in Development:

LRP6: axing axin

Development 2007 134: e303. [Full Text]  



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