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Development, Vol 99, Issue 4 473-480, Copyright © 1987 by Company of Biologists

JOURNAL ARTICLES

Rescue of developmental lens abnormalities in chimaeras of noncataractous and congenital cataractous mice

AL Muggleton-Harris, K Hardy and N Higbee
MRC Experimental Embryology and Teratology Unit, Medical Research Council Laboratories, Carshalton, Surrey, UK.

In the study of the lens of a congenital cataractous mouse mutant (CAT), it has been shown that a loss of growth regulation at the cellular level causes gross lens abnormalities. The phenotypic characteristics of the cataractous mouse lens are similar to those seen in human congenital cataract and thus serves as a model system for medical research. In this present investigation, we have demonstrated that the abnormalities of the congenital cataractous lens can be rescued by forming chimaeras between DBA/2 (a noncataractous strain of mouse) and the CAT mutant. This report describes the histological, cellular and biochemical analysis of the resultant chimaeric eyes, and discusses possible mechanisms by which these results were achieved.


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© The Company of Biologists Ltd 1987