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First published online August 18, 2003
doi: 10.1242/10.1242/dev.00728

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Cell boundaries: knowing who to mix with and what to shout or whisper

Anatomy and Developmental Biology, University College London, London WC1E 6BT, UK

View larger version (34K): [in a new window]   Fig. 1. The establishment of signalling regions at compartment boundaries in the Drosophila wing disc. The gene engrailed (en) is expressed in the posterior compartment of the wing disc together with hedgehog (Hh). At the boundary with anterior cells, Hh activates Decapentaplegic (Dpp), which is secreted into both compartments. At the dorsal-ventral (DV) boundary, wingless (wg) is expressed. Reproduced, with permission, from Wolpert et al. (Wolpert et al., 2002).

View larger version (77K): [in a new window]   Fig. 2. Lineage restriction in the rhombomeres of the embryonic chick. Single neuroepithelial cells labelled at early (during somite formation, left, red and orange) and at later (right, blue) stages of development are shown. The middle panel shows their labelled descendants mapped 2 days later. Cells labelled early and before boundaries have formed have descendants in more than one rhombomere (r). Reproduced, with permission, from Wolpert et al. (Wolpert et al., 2002) [adapted from Lumsden (Lumsden, 1991)].

View larger version (59K): [in a new window]   Fig. 3. Patterning of the wing disc along the anterior-posterior (AP) axis. Decapentaplegic (Dpp) protein is assumed to be a diffusible morphogen that forms an asymmetric gradient in both compartments. spalt and omb, targets of Dpp that are activated at specific threshold concentrations of Dpp. Reproduced, with permission, from Wolpert et al. (Wolpert et al., 2002).