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First published online November 17, 2003
doi: 10.1242/10.1242/dev.00848

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The immunoglobulin superfamily in Drosophila melanogaster and Caenorhabditis elegans and the evolution of complexity

MRC Laboratory of Molecular Biology, Cambridge CB2 2QH, UK

View larger version (24K): [in a new window]   Fig. 1. Overview of the procedures to determine the IgSF repertoire in fly and worm. The genome sequence is displayed as a black line, the predicted genes are depicted as thicker lines. The thick grey line (4) represents an additional exon found with GENEWISE. Red rectangles depict predicted IgSF domains, differently coloured rectangles are domains of other superfamilies.

View larger version (22K): [in a new window]   Fig. 2. Domain architectures I: cell-surface proteins, cell-surface receptors and cell-surface proteins with unusual domains. The domain architectures of IgSF proteins discussed in this work are shown as black lines representing their amino acid sequence and coloured symbols representing the domains. The legend for different domain types is at the bottom of Fig. 3. The two parallel, grey lines represent the cell membrane. Parts of proteins above the lines are extracellular, parts below the lines are intracellular. Drosophila proteins are in black, C. elegans proteins are in blue text. GPI, glycosyl-phosphatidylinositol anchor.

View larger version (24K): [in a new window]   Fig. 3. Domain architectures II: secreted, extracellular matrix and muscle proteins. The domain architectures of IgSF proteins discussed in this work are shown as black lines representing their amino acid sequence and coloured symbols representing the domains. The legend for different domain types is at the bottom. Drosophila proteins are in black, C. elegans proteins are in blue text. GPI, glycosyl-phosphatidyl-inositol anchor.

View larger version (12K): [in a new window]   Fig. 4. E-value distribution. The histogram shows the frequency distribution of E-values between pairs of experimentally characterised IgSF proteins in Drosophila. The x-axis displays bins of the negative decadic logarithm of the E-value. White columns, proteins of the same class; black columns, proteins of different classes.