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First published online May 23, 2006
doi: 10.1242/10.1242/dev.02418

Development 133, 2287-2290 (2006)
Published by The Company of Biologists 2006
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Getting to the guts of enteric nervous system development

Robert O. Heuckeroth1 and Vassilis Pachnis2,*

1 Washington University School of Medicine, Department of Pediatrics, 660 South Euclid Avenue, Box 8208, St Louis, MO 63021, USA.
2 Division of Molecular Neurobiology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK.


Figure 1
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  		Fig. 1. Acetylcholinesteratse histochemistry on a whole-mount preparation of newborn mouse gut highlights the network of enteric ganglia. A detail of the ENS plexus (stained for NADPH diaphorase) is shown in the inset. Image courtesy of Esther de Graaff (Erasmus University, Rotterdam, The Netherlands) and Robert O. Heukerch.

 

Figure 2
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  		Fig. 2. GFP+ cells in explants of hindgut (taken from RetTGM/+ embryos) maintained in control conditions or exposed to an L1 function blocking antibody for 18 hours. In the control explant, the cells are elongated and migrate in chains, except when undergoing cell division. After dividing, the daughter cells quickly become elongated and resume migration as a chain. When the activity of the cell-adhesion molecule L1 is perturbed, many solitary cells are observed (asterisks) that are round and do not migrate (Anderson et al., 2006Go). Image kindly provided by Richard Anderson and Heather Young (University of Melbourne, Melbourne, Australia).

 




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