Fig. 5. Reduction in cell proliferation of OPs in the CNS of TN-C-null
mice with a 129 genetic background. BrdU (green)/NG2 (red) double
staining experiments at P7, in the SVZ (A) and in the cortex (B) of an
heterozygous animal and in the cortex of a TN-C-null homozygous animal
(C). Very few BrdU-positive cells were NG2 positive in the SVZ, while
in the cortex, the OP (NG2-positive) population represents about a
third of the proliferative (BrdU-positive) cells (B). Note that in
TN-C-null homozygous animals (C), fewer double-stained cells were
found in the cortex in comparison with heterozygous littermates
(B). Scale bar: 50 µm.
