Fig. 10. Targeted injection of other Wnt antagonists has differential effects. (A) Control embryos. (B) Embryos injected animally with Xwnt5a mRNA display dorsal flexure. (C) Embryos injected vegetally with Xwnt5a are not ‘kinked’ but are foreshortened. (D) Embryos injected animally with Nxfz-8 mRNA display severe dorsal flexure. (E) Embryos injected vegetally with Nxfz-8 display two phenotypes. Many embryos do not display dorsal flexure (top), similar to other vegetally injected embryos in this study. Other embryos do display dorsal curvature (bottom). This phenotype may be due to higher diffusibility of the small, secreted Nxfz-8 protein.
