Fig. 4. (A) View of Cripto model superimposed onto the basic FGF structure (2bfh). The C
traces are shown. The Cripto and 2bfh traces are rendered in magenta and cyan, respectively. The r.m.s.d. of the backbone atoms (C, C-alfa and N atoms) for the two superimposed structures was 0.91Å on a total of 468 corresponding atoms. (B) Cripto model (C trace) with highlighted EGF (red) and CFC (blue) regions. The disulphide bonds (in yellow) are also shown. (C) Ribbon rendering of the Cripto model with all mutated residues drawn with a CPK representation. Mutations with a strong and less severe effect are indicated in blue and cyan, respectively while ineffective mutations are indicated in red. ß-strands are shown as green arrows and loops as yellow ropes. Orientation is different from A and B.
