Fig. 2. Patch-matrix organization at E18.5 in wild types and Gsh2 homozygous mutants. DARPP-32 immunohistochemistry outlines the dorsal striatum and shows intense labeling in striatal patches and the subcallosal streak (scs) of the wild type (A). Labeling can still be detected in the Gsh2 mutant but patches are fewer and smaller and labeling of the scs is weaker (B). At this stage, immunohistochemistry for the µ-OR shows patchy distribution and scs labeling in the wild type (C) and to a lesser extent in the Gsh2 mutant (D). Arrowheads in A-D show representative patches labeled with either DARPP-32 or µ-OR. CaBP expression in the Gsh2 mutant striatum (F) appears to be increased as compared to wild type (E). ac, anterior comissure; cc, corpus callosum.
