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Fig. 6. Morphology of an Otx2{lambda}/-; Gbx2–/– embryo at 10.5 d.p.c. Compared with wild-type (A) and Gbx2–/– (B) embryos, Otx2{lambda}/-; Gbx2–/– embryos (D) show compromised development and severe abnormalities of the anterior CNS; while, compared with the head-less phenotype of Otx2{lambda}/- embryos (C) it is evident that the anterior neural tube of Otx2{lambda}/-; Gbx2–/– embryos (D) develop morphological similarities having midbrain and forebrain. Moreover, the heart (D) reveals normal morphology when compared with hOtx12/hOtx12; Gbx2–/– embryos (Fig. 1D). Abbreviations as in previous figures plus, he, heart.





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