Fig. 9. Fate of rhombencephalic r4-r8 neural crest cells rostrally transposed into the Hox-negative domain. (A) Bilateral substitution of the quail rhombencephalic r4-r8 neural fold to the host Hox-negative neural fold (extending from diencephalon down to r2). (B) E7. Frontal view of a chimeric embryo showing the complete absence of upper face and lower jaw. (C) Rhombencephalic quail cells that have colonized the facial primordium contribute Schwann cells to the trigeminal nerve (D). Some rare graft-derived cells are identified as pericytes in vascular wall of blood lacunae (E) and into the choroid membrane capillaries (asterisk, F). (G) Quail cells are poorly present in ciliary muscles and absent from the cornea. Scale bar: 250 µm in C; 50 µm in D; 30 µm in E; 20 µm in F; 30 µm in G.

Return to article