Fig. 7. Model for localized regulation of Protein kinase A activity by Akap200. See Discussion for details. Red depicts filamentous actin in subcortical regions of nurse cells and ring canals, green symbolizes Akap200, dark blue is Pka-RII, pink is Pka-C; yellow circles and orange blobs are other proteins that regulate actin filament polymerization or function. Phosphorylation by Pka-C inhibits the actin-regulating activity of the yellow circle proteins in this diagram, whereas Pka-C phosphorylation is required for the orange blob proteins to regulate actin function properly. Pka-C* is a mutant isoform of catalytic subunit that is incapable of binding to Pka-RII.

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