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Fig. 2. Gas1-/- has limb abnormalities. Dorsal view of the
newborn forelimb (A,A',C,C') and hindlimb (B,B',D,D') paws of a control (con;
A-D) and a Gas1 mutant (-/-; A'-D') animal.
Gas1-/- forelimb and hindlimb paws are overall smaller and
have syndactyly between digits II and III (A',B'). White arrows indicate soft
tissue fusions and white arrowheads, disproportionally reduced digits. (C-D')
Skeleton of the paws stained with Alcian Blue and Alizarin red. Black
arrowheads indicate the reduction (C') or lack of (D') the second phalange of
digit II; black arrows, syndactyly of digits II and III (D'). (E) A table
summarizing the frequency of these skeletal defects in the Gas1
mutants.
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