Fig. 6. Effect of different cell death methods upon the regularity index and packing factor of the mosaics. An initial mosaic of 400 cells was created using the exclusion zone model (d_min=10 µm, =0.008; A=4 mm²). Cells were removed one-by-one until 40% of cells had been deleted. Starting with the same initial mosaic, all three methods (selecting cells either by smallest Voronoi area, smallest nearest-neighbour distance or at random) were tested. Hence the results for 0% cell death (showing the initial regularity) are the same for each method. Ten different initial mosaics were created, from which the mean and s.d. of the regularity index were calculated for each method.

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