Fig. 13. A proposed model for signaling events occurring during induction and patterning of the telencephalon within the anterior neural plate. Anterior neural plate fate is induced in the ectoderm by secreted BMP inhibitors (such as chordin), which start the expression of region-specific forebrain markers, like XBF-1 (telencephalon) and Xrx1 (retina). On this early anterior neural plate, ventral forebrain fates are induced by FGF8 and inhibited by the ADE, while the combined action of cerberus (and possibly other ADE-secreted signals) and FGF8 promotes dorsal telencephalic fates.

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