Fig. 8. The involuted ADME of stage 10.5 embryo can trigger expression of the dorsal telencephalic markers Xemx1 and eomes in chd injected animal caps. Animal caps (blue in schematic) from stage 9 uninjected (A-F) or injected (G-K) embryos were explanted, conjugated in pairs either without (A-C;G-I) or with (D-F,J,K) the ADME (red) from a stage 10.5 gastrula and grown to stage 30/31. Injected animal caps never express either Xemx1 (G) or eomes (H), but show activation of a control neural marker, Xrx1 (I). chd-injected caps conjugated with the ADME show activation of both Xemx1 (J) and eomes (K), whereas no activation of these genes or of Xrx1 is detected in conjugates between ADME and uninjected animal caps (D-F). Uninjected caps never show expression of Xemx1, eomes or Xrx1 (A-C).

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