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Fig. 2. Ebf1 inactivation induces a shift in thalamocortical and
corticothalamic connections. Coronal hemisections of E16.5 brains where
crystals of DiI (A-M) or DiI and DiA (N-P) were placed in several regions of
the neocortex of controls (left) and Ebf1-/- mutants
(right). Schematic representations of a dorsal view of the brain (A,D,G,K,N)
indicate the position of DiI and DiA crystals in the occipital (A,D), parietal
(G), frontal (K), or parietal and occipital (N) neocortex. The insertion sites
of DiI crystals are also visible in B and C (stars). The retroflexus tract,
which can be used as a morphological landmark, is indicated by a white
arrowhead (E,F,H,I,L,M,O,P). Open arrowheads indicate the medial boundary of
the thalamic domain where cell bodies and axons are labeled in wild-type
embryos (E,H,L,O). This wild-type boundary is indicated in
Ebf1-/- embryos (open arrowheads) and shows that position
of the labeled thalamic domains are shifted medially (F,I,M,P). dTH, dorsal
thalamus; Fr, frontal neocortex; IC, internal capsule; Ncx, neocortex; OB,
olfactory bulb; Occ, occipital neocortex; Par, Parietal neocortex; Str,
striatum.
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