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First published online September 2, 2003

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Development 130, e2005 (2003)
Copyright © 2003 The Company of Biologists Limited

IN THIS ISSUE

Left or right: 14-3-3E makes an early move


Left-right (LR) axis establishment during embryogenesis underlies the asymmetric body plan of adult animals, for example, the siting of the heart on the left side of the human body. On p. 4847, Bunney et al. report that the signalling molecule 14-3-3E is involved very early in LR patterning in Xenopus laevis. The researchers show that the treatment of newly fertilised eggs with Fusiococcin-A, a fungal toxin that interacts with 14-3-3 proteins, randomised on which side of the body the heart, gut and gall bladder developed in the embryos, as did the blockade of 14-3-3 function with a phosphopeptide containing a 14-3-3 interaction motif and the overexpression of 14-3-3E. Their demonstration that 14-3-3E is asymmetrically localised at the first cell division of fertilised Xenopus eggs identifies the earliest LR asymmetric molecular localisation in any species to date.


Related articles in Development:

Fusicoccin signaling reveals 14-3-3 protein function as a novel step in left-right patterning during amphibian embryogenesis
Tom D. Bunney, Albertus H. De Boer, and Michael Levin
Development 2003 130: 4847-4858. [Abstract] [Full Text]  




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