Supplementary Figure
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Fig. S1.
Diagrammatic representation of the molecular differences between FCs
(Ras-dependent) and FCMs (Notch-dependent). We show the subcellular location,
either known, presumed or tentative (question marks) of the proteins encoded by
the genes identified by microarray. Proteins with known functions in muscle
development, either differentially expressed in these two cell types (e.g.
Kirre) or not (e.g. Myoblast city), are shown in black; Proteins identified in
our screen our shown in green. Genes involved in signaling are listed in the
square boxes outlined in gray, with the exception of Calsyntenin-1, which is
known to undergo proteolytic cleavage and becomes internalized, this is
represented in more detail. Proteins involved in cell adhesion are listed close
to an orange line in the FC, and cytoplasmic membrane-bound proteins are listed
close to a blue line in the FCM cell. ECM, mitochondrial and cytoplasmic
proteins are listed in a patterned background outside of the cells, close to a
mitochondrial drawing or in the cytoplasm of the cells, respectively. Proteins
bound to intracellular membranous compartments (such as lysosomes or
endoplasmic reticulum) or released to their lumen are indicated by a rounded
blue rectangle. Molecular transporters, a nuclear importin receptor and a large
subunit ribosome export protein are listed close to the pore-shaped drawings at
the cell membrane or at the nuclear membrane, respectively. A dynactin motor is
shown close to parallel lines representing microtubules, whereas the fusion
process is detailed to the extent currently known. Nuclear proteins are listed
within the nucleus of the cell. The alternative splicing diagram represents the
potential involvement of CG9085 in this process in FCMs. Genes
with unclear roles in muscle development are listed outside the cells. Please
refer to the Results section and Table 1 for details and references.
