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Novel antagonist of BMP signalling

In a screen to identify neuralizing factors from a Xenopus anterior neuroectoderm (ANE) cDNA library, Osada and colleagues discovered XMAN1 (see p. 1783), a nuclear envelope protein that is a novel antagonist of BMP signalling — the first finding that a nuclear membrane protein functions in this way. XMAN1 is expressed in the ANE at the neural stage of development, and induces anterior neural markers in ectoderm explants and a partial secondary axis when expressed ventrally. Importantly, XMAN1 inhibits BMP signalling downstream of the Alk3 BMP receptor in various assays, an inhibitory activity that resides in the C terminus of the protein, which can bind to Smads 1, 5 and 8 — intracellular mediators of BMP signalling. Exactly how this nuclear envelope protein regulates BMP signalling requires further study, but these findings highlight a new role for such proteins in this pathway.

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XMAN1, an inner nuclear membrane protein, antagonizes BMP signaling by interacting with Smad1 in Xenopus embryos

Shin-Ichi Osada, Shin-ya Ohmori, and Masanori Taira
Development 2003 130: 1783-1794. [Abstract] [Full Text]  

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This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Search for Related Content