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First published online December 17, 2003

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Head start on homeobox gene expression

Otx2, a paired-type homeobox gene, plays a vital role during embryonic rostral head development in vertebrates but regulation of its expression is poorly understood. On p. 57, Kimura-Yoshida et al. describe the embryonic expression pattern of Fotx2, the pufferfish Otx2 gene. Then, taking advantage of the small size of the Fotx2 gene compared with Otx2, the researchers surveyed the entire Fotx2 genomic region for cis-acting regulators by examining expression of a lacZ reporter linked to different Fotx2 fragments in transgenic mice. They identified seven independent cis-regulators that mediated lacZ expression in spatiotemporally non-overlapping subdomains of the developing rostral head. Two of these regulators were also tested and found to work in zebrafish embryos. The researchers conclude that multiple cis-regulators in the Otx2 promoter are required to control the highly coordinated processes that occur during vertebrate head development.

Related articles in Development:

Characterization of the pufferfish Otx2 cis-regulators reveals evolutionarily conserved genetic mechanisms for vertebrate head specification

Chiharu Kimura-Yoshida, Kuniko Kitajima, Izumi Oda-Ishii, E Tian, Misao Suzuki, Masayuki Yamamoto, Tohru Suzuki, Makoto Kobayashi, Shinichi Aizawa, and Isao Matsuo
Development 2004 131: 57-71. [Abstract] [Full Text]  

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This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Search for Related Content