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Fig. 2. Clustering of genes expressed at each stage of endocrine development. These
clustered genes are also grouped according to their biological function. (A) A
GeneSpring clustering analysis that identified four groups of genes that were
specifically expressed in each stage of development: E7.5 endoderm, E10.5
PDX1+ pancreas cells, E13.5 NGN3+ endocrine progenitors,
and adult islets. For each group of genes, the X-axis represents the stage and
the Y-axis represents the normalized abundance (intensity) of each transcript.
Each line shows the normalized expression level of one gene during each stage
of development. (B) Pie charts of genes that were expressed at each stage of
development, clustered by biological function. For a more comprehensive
comparison of genes in each biological class, we have combined the temporally
and spatially regulated genes from the supplemental tables into one pie chart
per stage of development. The absolute number of genes in each biological
class is shown next to each pie sector. For a complete list of genes either
temporally or spatially enriched in each cell sample, see Supplementary
Tables.
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