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Fig. 3. (A-D) Xbh1 promotes ganglion cell differentiation in lipofection
experiments. Retinal precursors lipofected with GFP+vector DNA alone
(B), or with GFP+Xbh1 (C,D). Retinal layers are separated by
dashed lines (B,C) and are indicated in B as follows: GCL, ganglion cell
layer; INL, inner nuclear layer; ONL, outer nuclear layer; l, lens. (A)
Distribution of retinal cell types in lipofected clones. Ph, photoreceptors;
H, horizontal; B, bipolars; Am, amacrine; G, ganglion; Mü, Müller.
The proportion of each cell type is represented as average±s.e.m. The
experiment has been repeated at least three times for both GFP and
Xbh1. In the experiment represented here, n=3907 cells from
26 retinae for GFP, and n=2799 cells from 25 retinae for
Xbh1. Asterisks represent significant differences between
Xbh1 and GFP, as calculated by Student's t-test
(*P<0.05, **P<0.01,
***P<0.001). (D) Lower magnification image of section
shown in C; GFP-positive axons extend into the optic nerve (arrows).
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