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Fig. 2. Non-complementation between the doubleridge mutation and a null allele of Dkk1. (A) Normal limb development in Dkk1d/+ heterozygote; (B) Postaxial polysyndactyly in Dkk1d/– compound heterozygote; (C) Postaxial polysyndactyly in Dkk1d/d homozygote, (D) Postaxial polysyndactyly in Dkk1–/–. Forelimbs from E18.5 embryos were stained with alcian blue and alizarin red.





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