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Fig. 4. Effect of varying Dkk1 expression on development of anterior head structures. (A) Normal head development in Dkk1d/d homozygote; (B,C) two viable Dkk1d/– compound heterozygotes with closed eyes and hydrocephaly. (D-G) Skeletal preparations stained with Alcian Blue and Alizarin Red: (D) wild type at P0; (E) severely affected Dkk1d/– compound heterozygote with anophthalmia at P0; (F,G) head development in two Dkk1–/– null homozygotes at E18.5.





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