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Fig. 6. Cyclin A2/cdk2 overexpression results in disruption of skin architecture. Embryos were injected with RNAs encoding cyclin A2 with cdk2 (A-C) or ß-gal as a control (D-F), along with GFP as a lineage tracer. Embryos were fixed at stage 23, sectioned, then stained for expression of the skin marker, epi (A,D), confined to the epidermis in these sections. Region of epi expression deep within the thickened skin is indicated by a white arrow. GFP fluorescence (B,E). DNA is stained with Hoechst in blue (C,F). Alternatively, uninjected embryos or embryos injected with RNAs encoding cyclin A2/cdk2, as indicated, were photographed in whole-mount (G). A raised hyperpigmented lump, which often formed after cyclin A2/cdk2 injection, is indicated by the black arrow.





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