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Fig. 1. twister mutants display aberrant motor axon trajectories. (A) The three primary axons, CaP, RoP and MiP, initially share a path from the spinal cord to the choice point, at the level of the horizontal myoseptum (broken line). (B-D) Wild-type (26 hpf) and twister mutant embryos stained with znp-1 antibody (black line indicates the ventral aspect of the spinal cord, white line the level of the choice point). (B) In wild-type embryos, axons migrate to the choice point, from which the CaP axon migrates into the ventral myotome (white arrow), whereas the MiP projects a collateral into the dorsal myotome (white arrowhead). (C) In heterozygous twister mutant embryos, primary motor axons develop ectopic branches at the region of the choice point (black arrows). (D) In twister homozygous mutant embryos, motor axons form ectopic branches at the choice point (black arrow) or in the ventral myotome (yellow arrows). In addition, motor axons are stalled along the common path (blue arrows; all lateral views).

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