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Fig. 4. Ectopic expression of MKP3 blocks RAS/MAPK signaling. (A) mkp3
expression constructs. Sequence represents the phosphatase active site. (B)
Xenopus animal explant assay. Explants injected with activated forms
of RAS exhibit induction of Xbra, while co-injection of mkp3
suppresses RAS activity. The inactive mutant construct mkp3::C292S
had no effect on the activated form of RAS. (C-J) Ectopic expression of
mkp3 or mkp3::C292S can suppress or enhance, respectively,
the expression of sef and spry4 at gastrula stage.
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