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Fig. 3. Expression of a stabilized form of ß-catenin promotes neuronal
differentiation in the presence of Fgf2. (A) A model depicting the possible
actions contributing to the increased neuronal population after activation of
the canonical Wnt pathway. NP, neuronal progenitor; GP, glial progenitor; N,
neuron; G, glia. (B) NPCs were infected with a retrovirus encoding either GFP
alone (control) or both GFP and S33Y ß-catenin, and the percentage of
TuJ1+ cells among GFP+ cells was determined at the
indicated times after culture in the presence of Fgf2. Data are the
mean±s.e.m. of values from six samples, and similar results were
obtained in two independent experiments. (C) The percentage of
HuC/D+ cells among GFP+ cells after culture for 2 days
in the presence of Fgf2 was determined. Data are the mean±s.e.m. of
values from eight samples, and similar results were obtained in three
independent experiments.
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