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Fig. 5. Inhibition of spry2 alters dorsoventral patterning. (A-D) Embryos co-injected with mo-spry2 and dn-spry2 display severely reduced bmp2b expression. (E-L) Increased Bmp signalling levels cause alterations of DV patterning in spry2 loss-of-function experiments. (F) Injection of mo-spry2 causes an expansion of cyp26a-expressing dorsal anterior neurectoderm, compared with (E) wild type (wt), which is abolished by co-injection of bmp2b (G) similar to inhibition of neural fate after injection of bmp2b alone (H). (I,J) mo-spry2-injected embryos display a reduction of the foxi1-expressing ventral epidermis. Co-injection of bmp2b rescues and even enlarges the epidermal territory (K) similar to a single bmp2b injection (L). (A-D) Shield stage; (E-L) midgastrula stage. (A-D,E-L, top) Lateral views. (E-L, bottom) Animal pole views; all embryos are dorsal towards the right.





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