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Fig. 9. Early development of the cerebellum. (A,B) Incorrect regulation of Math1 expression in the anterior rhombic lip. At E11.5, Math1 expression is enhanced in the Psen1 mutants (B, upper panel) in comparison with wild type (A, upper panel). At E13.5, strong Math1 expression persists in the medial rhombic lip of the mutant (arrow in B, middle panel) but becomes downregulated in the wild type (A, middle panel). At E14.5, Math1-positive cells are spreading over the cerebellum in the wild type (A, lower panel), but accumulate medially in the mutant (B, lower panel). Notice the thinned rhombic lip and overall abnormal morphology of cerebellum in the mutant. (C-F) Downregulation of Gbx2 expression in anterior hindbrain. (C,D) Gbx2 expression is downregulated in the mutant. Dorsal view of wild type (C) and mutant (D) embryos after whole-mount in situ hybridization. Gbx2 expression is lower in dorsal r1 of the mutant (arrow in D). (E,F) Flat-mount preparations of hindbrain following in situ hybridization with Gbx2. Notice downregulation and incorrect pattern of expression (asterisks in F) in the mutant anterior hindbrain.

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