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Fig. 7. The mitotic-to-endocycle transition in Drosophila follicle cells
is executed by Notch-dependent control of cell cycle regulators. (A) A
proposed scheme showing that the Notch pathway induces a switch from the
mitotic-to-endocycle by controlling the activity of key cell-cycle regulators;
cyclin-dependent kinases that control M- and S-phase entry and the
APC/ubiquitination complex that regulates degradation of cyclins. Notch
activity controls these regulators by downregulating String and Dacapo, and
activating Hec1/CdhFzr. (B) The molecular model in which Notch
activity executes the mitotic-to-endocycle switch by regulating all three
major cell cycle transitions. Repression of String blocks M-phase, activation
of Hec1/CdhFzr allows G1 progression and repression of Dacapo
assures entry into S-phase.
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