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First published online December 30, 2003

Development 131, 205e (2004)
© The Company of Biologists Limited
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In this issue

Go with the flow


For mammalian and bird embryos to survive, a complex vascular system must form in the yolk sac surrounding the embryo and connect correctly to the embryonic circulation. On p. 361, le Noble et al. propose that haemodynamic flow plays a central role in arterial-venous patterning and differentiation within the chick yolk sac. The researchers show that during this developmental process, thin vessels from the arterial domain of the sac disconnect from the arterial tree before reconnecting to the venous system, indicating that arterial-venous differentiation is plastic. To test whether haemodynamic flow is involved in this plasticity, le Noble and colleagues altered the flow in the developing vasculature. Their results, which include a complete loss of arterial-venous patterning and differentiation in the absence of perfusion, suggest that haemodynamic flow may be the master regulator of yolk sac vascular development.


Related articles in Development:

Flow regulates arterial-venous differentiation in the chick embryo yolk sac
Ferdinand le Noble, Delphine Moyon, Luc Pardanaud, Li Yuan, Valentin Djonov, Robert Matthijsen, Christiane Bréant, Vincent Fleury, and Anne Eichmann
Development 2004 131: 361-375. [Abstract] [Full Text]  




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