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Fig. 7. Inhibitors of VEGF signaling block neural tube-derived vascular plexus
formation. 8.5 dpc Flt1+/–,
eGFP+/– mouse presomitic mesoderm grafts were placed
beside stage HH 10-13 quail neural tubes in collagen gels and cultured for 72
hours. Panels on the right (B,D,F) show eGFP expression that identifies mouse
tissue. Co-cultures were grown in basal medium alone (A,B) or with added 1
µg/ml Flt/Fc (C,D) or 10 µM SU5416 (E,F). n
4 for all three
conditions. Scale bar: 200 µm for all panels.
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