|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
|
Fig. 2. Hair-specific ablation of the Bmpr1a gene in mice.
Hair-Bmpr1a KO mice (right) lack external hairs at the limbs
(arrowheads) at P30 (A). (B-D) The right hindlimbs of control mice at P30: (B)
whole limb; (C) instep; (D) outstep. (E-G) Hindlimbs of P30
Hair-Bmpr1a KO mice: (E) whole limb shows an abnormal spreading of
first digit and malformed claws in hindlimbs; (F) instep; (G) outstep. (H,I)
HE stained section of forelimb from control mice (H) and Hair-Bmpr1a
KO mice (I) at E15-16. TUNEL analysis in adjacent section of control mice (J)
and Hair-Bmpr1a KO mice (K) (see boxed areas in H and I). The number
of TUNEL-labeled nuclei in first digit of Hair-Bmpr1a KO mice limb at
E15-16 was reduced (K) compared with control mice (J). In situ hybridization
analysis of Bmpr1a using an exon 2-specific probe in a section from
P30 control (L,M). The expression of Bmpr1a is efficiently abolished
in the P30 Hair-Bmpr1a KO mice (N). c, cortex; irs, inner root
sheath; m, matrix; me, medulla; ors, outer root sheath. Scale bars: 20 mm in
A; 2 mm in B-G; 100 µm in H,I; 50 µm in J-N.
|
