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Fig. 1. A comparison of notochords. (A) At 24 hours post fertilisation (hpf), the zebrafish notochord (red) occupies a considerable volume of the embryo. (B) This is especially apparent in cross-section, where the area of the notochord is nearly equal to that of the neural tube. (C) By contrast, in an embryonic day (E) 9 mouse embryo, the notochord is proportionally smaller, (D) taking up a cross-sectional area of only a fraction of the neural tube. (A) Lateral view of live 24 hpf zebrafish embryo. (B) Trunk-level cross section of a 24 hpf zebrafish embryo. (C) Three dimensional reconstruction of an E9 mouse. White line indicates level of section shown in D, with notochord highlighted in red. (C,D) Adapted, with permission, from the Edinburgh Mouse Atlas Project (Baldock et al., 2001; Brune et al., 1999).





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